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Additionally, it is involved in preserving the structural integrity of the lungs and gastrointestinal tract, where it is involved in cellular processes linked to tissue maintenance

In this review, we introduce the history and structure of the SIRT protein family, discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family, elaborate on the regulatory roles of SIRTs in human disease, summarize SIRT inhibitors and activators, and review related clinical studies.