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Notably, preclinical studies in animal models first demonstrated this synergy co-administration of an amylin analog with a GLP-1 analog produced far greater weight loss than either agent alone paving the way for trials of the combination in humans
To partially compensate for this, patients are often given high systemic doses, which may increase brain exposure but also lead to significant off-target toxicity
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doi: 10.1210/jc.2010-2905 49 FallahiPFerrariSMRagusaFRuffilliIEliaGPaparoSRet al
