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Author Contributions Concept and design: Takayoshi Tsubaki, Mitsuhiro Morikawa, Takanori Goi, Yasuo Hirono Acquisition, analysis, or interpretation of data: Takayoshi Tsubaki, Mitsuhiro Morikawa, Takanori Goi, Yasuo Hirono Drafting of the manuscript: Takayoshi Tsubaki Critical review of the manuscript for important intellectual content: Mitsuhiro Morikawa, Takanori Goi, Yasuo Hirono Supervision: Mitsuhiro Morikawa, Takanori Goi, Yasuo Hirono References 1.Institute of Medicine (US) Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline