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Yildiz A, et al
Prostanoid receptor agonists for glaucoma treatment

However, this conformational change reduces the space available to accommodate the -helix of the peptide increasing the steric hindrance between the bulky ionic lock (R17 Cagri- E14 Cagri ) and ECL2

Increased mitochondrial membrane permeability leads to the release of cytochrome c (Cyt c) from the mitochondria into the cytoplasm
