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Melbourne: Monash University

Overexpression of copper/zinc superoxide dismutase does not prevent neonatal lethality in mutant mice that lack manganese superoxide dismutase

mTORC1 also regulates autophagy at the transcriptional level by modulating localization of transcription factor EB (TFEB), a master transcriptional regulator of lysosomal and autophagy genes (reviewed in ref
In these preclinical systems, APAP exposure leads to a rapid decline in intracellular Mg 2+ , accompanied by reduced ATP production and increased susceptibility to stress ( This magnesium loss is mechanistically linked to upregulation of the magnesium efflux transporter CNNM4, observed in both animal models and liver tissues from APAP overdose patients ( 2+ efflux from cytosol and mitochondria, a process exacerbated by mitochondrial membrane depolarization (71)
