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Automated tandem mass spectrometry for mass newborn screening for disorders in fatty acid, organic acid and amino acid metabolism

(33) provided mechanistic depth by demonstrating that carnitine orotate complex increases carnitine acetyltransferase (CrAT) and -oxidation-related proteins (CPT1, PPAR, UCP2) while inhibiting SREBP1c nuclear translocation and downstream target gene expression ( Hmgcr, Srebp2, Pcsk9, Ldlr ) in HFD-fed mice

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Complement Ther Med 2011;19(4):216-227