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10.1016/j.cell.2013.03.030 Summary Keywords astrocyte, glutathione S-transferase, GSTM1, inflammation, neuron, aging Citation Matoba K, Dohi E, Choi EY and Kano S (2023) Glutathione S-transferases Control astrocyte activation and neuronal health during neuroinflammation

For 5-amino-1MQ specifically: Preclinical studies have not prominently described heart rate elevation as a dominant signal The mechanism (NNMT inhibition, NAD+ preservation) does not have the same direct cardiac implications as nuclear receptor agonism Human cardiovascular data at clinically relevant exposures are limited For physicians, the current evidence base does not support a major cardiovascular safety flag, but the limited human dataset means confident statements are premature

He was also honored with the Regents Medal for Excellence in Teaching for his dedication to music education