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Description
Frequent coexpression of MRP/GS-X pump and -glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells and normal mouse tissues
One reason for this is that the level of glutathione will fluctuate throughout the day from its lowest in the early morning to depletion from routine exposure to toxic substances (like alcohol), pathogens, cigarette smoke, car exhaust, drugs, certain foods, stress level, illness, and many similar factors, so repeated testing could be required to set a baseline
Serum drug concentrations may be obtained but do not correlate well with toxicity (40)
Post-translational modifications in GPCR internalization
