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Anuj Chopra Dermatologist 13 years experience overall 1200 Consultation fee at clinic Dr
Mechanistically, -Syn oligomers interact with mitochondrial respiratory chain complex I, impairing its function, leading to mitochondrial membrane potential depolarization, and promoting the release of proapoptotic factors into the cytoplasm
Small-molecule inhibitors of the GSH pathway, such as buthionine sulfoximine (BSO), block -glutamylcysteine ligase and GSH biosynthesis, thereby exacerbating the oxidative stress elicited by radiotherapy and cisplatin [214,215,216]
Arch Toxicol (2018) 92:262943
