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As noted above, astrocyte reactivity is associated with diverse changes in molecular expression that can vary from mild to pronounced and that are highly context dependent

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At the same time, Akt phosphorylates and inactivates forkhead box O (FoxO), thereby inhibit the responsible for proteolysis ubiquitin ligases: muscle-specific RING finger-1 (MuRF-1) and muscle atrophy F-box protein (atrogin-1), (for review see [27,28,29])

Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells