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Therefore, we believed that Ag did not cause ferritinophagy and ferroptosis in hepatocytes and macrophages in the fibrotic liver, which was consistent with the previous in vitro experimental results of Ag intervention in AML-12 cells and RAW264.7 cells

doi: 10.1083/jcb.201709137 76 ZhangKWongHNSongBMillerCNScheunerDKaufmanRJ

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Mechanistically, the reductive stress observed in R120G mutant mice was attributed to activation of the nuclear factor (erythroid-derived 2)-like 2 (NRF-2) signaling pathway, which transcriptionally upregulated the mRNA or/and protein expression of key antioxidant enzymes ( e.g