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PMID: 39957487 CNS Neurosci Ther Berberine Alleviates Kainic Acid-Induced Acute Epileptic Seizures in Mice via Reshaping Gut Microbiota-Associated Lipid Metabolism

Facilitation of Surgical Innovation: Is It Possible to Speed the Introduction of New Technology While Simultaneously Improving Patient Safety
This study positions curcumin as a multi-target agent addressing both mitochondrial dysfunction and epigenetic dysregulation in diabetic bone disease, with an excellent safety profile, as only mild gastrointestinal discomfort has been reported as the primary adverse effect, even at high doses (5008000 mg/day) and during long-term administration (up to 12 months)

This finding reinforced the in vivo observations, demonstrating that Gepon directly downregulates inflammatory cytokine production in monocytes
