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The analgesic mechanisms of cannabinoids involve both direct suppression of excitatory and inhibitory neurotransmitter release via synaptic vesicle modulation, and indirect modulation of neuronal excitability through inhibition of voltagegated ion channels [344]

Drug Metab Rev 36:805822 Hsu S-H, Wang B, Kota J, Yu J, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula RR, Mao H, Wei M, Clark KR, Mendell JR, Caligiuri MA, Jacob ST, Mendell JT, Ghoshal K (2012) Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver