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If the clinical history and examination reveal neuropathy, then screening for a cause should be performed, including diabetes, hypothyroidism, vitamin deficiencies (B 12 and folate), autoimmune conditions and alcohol misuse, as indicated

The most important isoforms in muscle research are: IGF-1Ea the predominant circulating form, produced in the liver in response to GH, responsible for systemic anabolic and proliferative IGF-1 signalling via the IGF-1 receptor (IGF-1R) IGF-1Ec (MGF in humans

Kedir et al., 2024)

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