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Xiong et al., 2012), ArfGAP1 inhibition may offer an alternative therapeutic target for attenuating LRRK2 activity and toxicity in PD

[DOI] [PMC free article] [PubMed] [Google Scholar] 30.DeFronzo R, Fleming GA, Chen K, Bicsak TA

In 2017, Neelakantan and colleagues first systematically characterized 5amino1mq during screening for selective NNMT inhibitors, with findings published in Biochemical Pharmacology - marking the official discovery and public reporting of the compound.Through structural modification of quinolinebased precursors, the team identified 5amino1mq as a small, membranepermeable molecule with the chemical formula CHN.With an extremely low IC value, it became one of the most promising selective NNMT inhibitors available at the time, with high specificity and no significant inhibition of other metabolically relevant enzymes

The article emphasizes the need for further research to fully understand their effects and potential in prostate health management