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Description
Soxhlet extraction typically requires 46 h per cycle (66), with some processes extending beyond 24 h (67)
Any add-ons at the end will add 5-15 minutes, and allow another 5-10 minutes to unhook everything
Constipation is the most common gastrointestinal dysfunction in PD
This limitation matters because repeated-dose toxicity guidelines normally expect systematic clinical observations, body weight tracking, hematology, clinical chemistry, organ weights, and histopathological examination under a defined study design
