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Recent B12 administration: Therapeutic injections for deficiency can temporarily raise levels significantly

The mutations in the CASR gene that are associated with type 5 Bartter are all activating mutations and they are inherited in an autosomal dominant manner

One potential mechanism is the Nrf2-ARE pathway, which induces a phase 2 detoxification response that promotes disruption of Nrf2-Keap protein interactions, translocation of Nrf2 to the nucleus, and regulation of target gene expression through the ARE, enhancing cellular defense against oxidative damage (Hu et al., 2004

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