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doi: 10.1016/j.ijpharm.2020.119553
Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility
Enhancement of anti-oxidant capacity: curcumin increases the levels of anti-oxidant enzymes such as catalase, superoxide dismutase, and glutathione in the nervous system, skeletal muscles, and circulatory system, mitigating oxidative stress [74]
10.3389/fnmol.2022.944693 113 PattonE
