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Description
AHR, a hallmark of allergic asthma, is intricately linked to gut microbial composition and diversity through immune crosstalk

NP: bioanalytical method development and validation

Collectively, the synergistic action of AGE-RAGE signaling, metabolic rewiring, and oxidative stress in the DW microenvironment creates a powerful, self-reinforcing circuit that locks macrophages into a persistent M1 state, thereby perpetuating chronic inflammation and impeding the resolution of healing (Figure 3)

Gonzalez-Burgos and Lewis, 2008