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Richardson, R

For the first time in history, high school athletes are training more like pros than kids multi-sport schedules, club travel, off-season showcases, strength training, nutrition expectations, recruiting pressure, long commutes, poor sleep, and the increasing belief that more is better. Their biology is being asked to mature faster than their endocrine system, and their recovery capacity isnt built for the volume they endure

Organization, The global burden of disease: 2004 update, 2008

Another study in a Danish population-based cohort found an increased risk for BCC, SCC, and CM, with ever use of doxycycline with an incidence rate ratio (IRR) of 1.3 (95 % CI = 1.21.3), 1.3 (1.21.5), and 1.1 (1.01.2), respectively [131]