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Metalloreductase six-transmembrane epithelial antigen of prostate 3 (STEAP3) possesses ferrireductase activity, reducing Fe to Fe 2 , which is then released into the cytoplasm via DMT1, contributing to an unstable iron pool (Pantopoulos, 2004

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4 DrugBank / PharmacologySelank pharmacokinetics: rapid plasma degradation (half-life on the order of minutes), relevant to route of administration

* While the oxidative phase is sufficient for the production of the required NADPH, the non-oxidative phase allows for recycling of ribose 5-phosphate into glucose 6-phosphate Cell requires NADPH and ATP - As is the case with the scenario where the cell requires high amounts of NADPH, this scenario involves both the oxidative and non-oxidative phase