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Description
60% had an ECOG PS of 1

It was generally believed that the mutation of epigenetic factors was mainly involved in the conversion of HSPCs to pre-LSCs, and involved mainly DNA methyltransferase 3A (DNMT3A) and Tet methyl cytosine dioxygenase 2 (TET2), which made HSCs more prone to leukemogenesis (152)

J., Kim I

6.1 Ferroptosis and apoptosis Apoptosis, the first identified regulatory cell death modality, is governed by apoptosis-related genes