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Therefore, chronic stress-induced dysregulation of the HPA axis, potentially mediated by imbalances in gut microbiota, might be a crucial link between dysbiosis and the progression of AD (Figure 1)

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For example, cholesterol oxidation derivatives, such as 7-hydroxycholesterol and 7-ketocholesterol, are significantly elevated in sarcopenia patients and exert cytotoxic effects on myoblasts and myotubes (56)