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That is, once the treatment has stopped, patients vary widely in how quickly they weaken their colonisation and how long they may remain colonised (76).A heterogeneous distribution of gut bacteria throughout the gastrointestinal tract creates a significant risk that modified bacteria will not be able to effectively colonise their preferred area (77, 78)

There is a theoretical concern, supported by some biological evidence, that elevated IGF-1 activity in a patient with occult or a history of certain hormone-sensitive cancers could be problematic

Specifically, it lacks methionine, which is vital in new blood vessel growth and needed to produce cysteine, which is the primary precursor to the body's natural production of the antioxidant, Glutathione

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