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2-adrenoceptor agonists Clonidine gel: A randomized, double-blind, placebo-controlled, parallel-group, multicenter trial showed that topical clonidine gel significantly reduced the level of pain in subjects with DN in whom there are functional (and possibly sensitized) nociceptors in the affected skin

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Wt+R+E mice took significantly less time to transverse the 0.6 cm beam (11.84 s 0.65 SEM, p = 0.03) compared to Wt+R+V at day 42 (15.22 s 1.08 SEM) (Fig