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104 Furthermore, a study that examined the magnesium status of more than 1,000 women with PCOS found lower magnesium levels were associated with worse insulin resistance and higher testosterone levels

Translational studies using exosomes showed a relationship between the epigenetic modulation of glutamatergic function and a brain metabolic dysfunction known as insulin resistance (IR) as showed by an increase and sex-specific phosphorylation in the expression of IRS1, a key marker of the insulin signaling cascade, in discrete exosomes enriched for the neural cell adhesion molecule L1 (L1CAM), a protein highly expressed in the brain [52, 70,71,72]

They can influence a wide range of physiological processes, including metabolism, tissue repair, inflammation reduction, and hormone regulation

Seebohm and Schreiber, 2021), PKA and PKC (Mamenko et al., 2013