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NOX-2 derived ROS play a pivotal role in enhancing IFN- production through intricate mechanisms involving the activation of signaling pathways, including c-Jun N-terminal kinase (JNK), signal transducer and activator of transcription 1 (STAT-1), NF-B, and T-bet

From January 2022, the use of the new Clinical Trials Information System (CTIS) become compulsory in all EU and EEA countries

56 , 57 Studies exploring the role of FGF21 in the metabolism of butyrate indicate that FGF21 is activated by butyrate and stimulates fatty acid oxidation in the liver

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