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Reduced levels of plasma medium and long chain acylcarnitines, seen in other autistic participants (Figure 5, Groups 5 and 7) can result from a reduced dietary intake of fatty acids or from an inhibition of long chain fatty acid entry into the mitochondria upon increased lactate and downstream inhibition of carnitine palmitoyltransferase 1 (CPT1) activity (67)

While mammals carry eight genes encoding canonical GPX, proteins such as GST [26] and peroxiredoxin [27] also show GSH-dependent peroxidase activity to some extent

[DOI] [PubMed] [Google Scholar] (137).Seidel C

Targeting inflammasome activation, inhibiting caspase-1, employing anti-inflammatory agents, and modulating the gut microbiota and bile acid metabolism represent promising avenues for developing novel treatments for this common and potentially life-threatening condition