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Start at 200 mcg daily and increase gradually over 2-3 weeks
Phase 2 trial (NEJM 2023) reported 24.2% mean weight loss at 48 weeks with 12 mg/week retatrutide, with gastrointestinal adverse events rising sharply at the 8 mg and 12 mg doses
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Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors
