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FDA's evaluation concluded that the criteria weighed against placement on the list, citing inadequate physicochemical characterization, immunogenicity concerns from impurities and aggregates, lack of clinical effectiveness data for any approved use, and absence of published human exposure data for the proposed subcutaneous and topical routes

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A point worth mentioning is the concern around BPA in plastic containers

Inflammation Reduction and Pain Relief Inflammation is the bodys response to injury, but too much inflammation can slow down healing and cause chronic pain