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They need to pull sufficient airflow in any condition, and you need to be sure you have enough surface area to do that

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In addition, the concentrations of IL-1, IL-6, and TNF- were specifically quantified using mouse ELISA kits (Absin)

From the article: We have identified a specific signal that is generated in visceral fat, released into the blood that gets through the blood brain barrier and into the brain where it activates microglia and impairs cognition. Visceral fat as the ring leader: They looked further and found that just transplanting the visceral fat caused essentially the same impact as obesity resulting from a high-fat diet, including significantly increasing brain levels of interleukin-1 beta and activating microglia