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However, it exhibits low cell membrane permeability and demonstrates substantial toxicity in animal models, thereby constraining its potential application as a therapeutic agent (Zweygarth et al., 1986)
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134 Leukemia is characterized by the uncontrolled proliferation of undifferentiated myeloid or lymphoid progenitors, impeding the normal function of hematopoietic cells and affecting the development of non-hematopoietic cells
doi: 10.1053/j.gastro.2021.10.040 13 BornsteinS
