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Inhibition of the JAK/STAT3 pathway is an important strategy for improving UC

Paraquat, a redox cycler that produces superoxide anion, has been reported to stimulate GPx-1 promoter activity (89), and p53 can upregulate GPx-1 transcription through its action at a classic p53-consensus binding site (177, 349)
Reproduction 145 , R107R116 (2013)
After subtraction of the glutathionyl-moiety, compound 17 was most likely a conjugate of the oxylipin keto-octadecadienoic acid