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Those with the MTHFR genetic mutation, certain developmental delays in children, and other conditions linked to impaired methylation often find synthetic forms ineffective, making methylcobalamin injections vital

Diet alone often falls short, leaving you tired or tense

Additionally, several rare pathogenic variants in SCN9A have been identified in patients carrying small fiber neuropathy [92], further underscoring the critical involvement of this gene in potentiating the mechanism of neuropathic pain

It also modulates matrix metalloproteinases in a way that removes damaged collagen while simultaneously encouraging healthy replacement