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B12 plays a crucial role in maintaining skin moisture by supporting the skins natural barrier function

The aggressive factors include acid, pepsin, Helicobacter pylori , stress, alcohol, administration of nonsteroidal anti-inflammatory drugs, and protective mechanisms which are present in the duodenal mucosa and include mucus, bicarbonate, prostaglandin, blood flow, the antioxidant system, sulfhydryl compounds, nitric oxide, and cell proliferation [13]

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