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06 Persistent injection-site redness or hardness Rotate injection sites more aggressively (abdomen, front of thigh, upper arm) and avoid reusing the same spot for at least 7 days
10.1126/sciadv.abm9718 96 KeirH

PMID: 33500247 Mol Cell One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages
Your healthcare provider can assess this through blood tests