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Although research in this area remains limited, that sex hormones affect the activity of alcohol-metabolizing enzymes is suggested by the finding that castration in male rats reduced the in vivo rate of ADH degradation, leading to increases in ADH protein content and ADH activity to levels that are comparable to those of female rats (210)

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This metabolite can accumulate to high levels when -ECS is overexpressed alone, either in the cytosol or the chloroplast (Noctor et al., 1996, 1998a