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Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, et al

2 Overview of idiopathic pulmonary fibrosis 2.1 Characterization of idiopathic pulmonary fibrosis Histologically, IPF is characterized by UIP patterning, in which the lung interstitiuma band-like tissue supporting alveoliundergoes ECM deposition and architectural disorganization ( 2.2 Pathogenesis and therapeutic targets of idiopathic pulmonary fibrosis 2.2.1 Alveolar epithelial cell injury and abnormal repair The etiology and pathogenesis of PF, particularly IPF, are largely undetermined, but notable advancements and consensus have been achieved in the field

The "copper uglies" theory extends the documented MMP mechanism into a specific claim: that in ordinary use on intact skin, this remodelling activity can temporarily outpace new collagen synthesis, producing a visible dip in skin appearance before things improve

Similarly, the metabolic heterogeneity and adaptive responses in TNBC poses numerous challenges to the clinical application of metabolic therapy