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M., Mohammadi S., Isberg R
I believe this is very conservative given the Phase 2b PYR-210 clinical trial showed a 57% treatment effect and the hurdle for success in the current Phase 3 PIONEER trial is only 28%
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Tfr1 deficiency in mice protects them from metabolic dysfunction induced by high-fat diets by impairing intestinal lipid absorption, although the underlying mechanism of the adipocyte-intestine link is not fully understood (149)
