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Clinical trials have demonstrated a 65 percent reduction in vertebral fracture risk and a 35 to 53 percent reduction in non-vertebral fracture risk after 20 months of treatment at 20 micrograms per day

Altered expression of TREK1, TREK2 and TRAAK potassium channels, M-type (KCNQ) channels, K V 1.1 and K V 4.3 have all been attributed to treatment with oxaliplatin (Descoeur et al., 2011

doi: 10.1016/S0166-0934(00)00301-3 152 TahmazNSoutarACherrieJW