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[73] [74] [75] It is synthesized by some bacteria in the gut microbiota in humans and other animals, but it has long been thought that humans cannot absorb this as it is made in the colon, downstream from the small intestine, where the absorption of most nutrients occurs

The body has already attempted and largely completed its healing response for old injuries

However, clinical trials assessing the efficacy of these techniques exclude the majority of the patient population with red knees, patients with large lesion size, high mechanical demands, older age, inflammation, infection, and other systemic diseases

Studies demonstrate the peptide reduces markers of oxidative damage including lipid peroxidation and protein oxidation in brain tissue, suggesting antioxidant mechanisms that could protect neurons from stress-related damage