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They may be useful for people with gastrointestinal issues, older adults, vegans, and vegetarians
doi: 10.1016/j.atherosclerosis.2008.09.015

However, the largest Phase IIb trial involving 536 participants failed to demonstrate statistically significant weight loss compared to placebo at the primary 12-week endpoint, leading to development termination in 2007

Long-term reactions are still unclear
