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This effect was associated with increased expression of IGF-1 and VEGF in the primary ossification zone.103 Altogether, the bone anabolic actions of the GH can be, at least in part, mediated by paracrine IGF-1 signaling, which enhances osteoblast activity.104 In fact, the only administration of recombinant IGF-1 to healthy participants results in an increase in circulating levels of bone remodeling markers
D., Savino, E., Girometta, C., Brandalise, F., & Rossi, P
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Irigoyen, P., Mansilla, S., Castro, L., Cassina, A
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