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However, the kinetic patterns do not support a ping-pong mechanism and the nonenzymatic first reaction with a second order rate constant of 0.6 M 1 s 1 is too slow to explain the rapid turnover 3,12,14,15,30

ASS: argininosuccinate synthase

313 Oleanolic acid induces autophagy and apoptosis in colon cancer cells by modulating the AMPK-mTOR signaling pathway, thereby exerting therapeutic effects against colorectal cancer

Gastrointestinal malignancies, comprising a wide range of tumors within the digestive tract, represent an essential health challenge worldwide, and are distinguished by high incidence and mortality rates