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Openings between defective endothelial cells explain tumor vessel leakiness
[7] This decline correlates directly with increased oxidative stress markers and age-related health issues
Additionally, this study showed that benfotiamine and its metabolites directly affect Nrf2 stability by interacting with Keap1 and thus releasing Nrf2 to translocate to the nucleus and activate the transcription of antioxidative genes [21]
EMBO J 28:28612873 Zechmann B, Mller M, Zellnig G (2006a) Intracellular adaptations of glutathione content in Cucurbita pepo (L.) induced by reduced glutathione and buthionine sulfoximine treatment
