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brevis [LbNOX (Titov et al., 2016)] was rationally mutated to confer NADPH specificity, in a construct named TPNOX ( The Pentose Phosphate Pathway The PPP is thought to be the primary source of cytosolic NADPHalthough whether this is true for all cell types and circumstances is less clearand is required to support the basal NADPH/NADP ratio