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NaHCO 3 : Not recommended except if there is refractory acidosis, weak recommendation, low quality evidence (2C)

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European Heart Journal

Synthesis of adefovir prodrug (adefovir dipivoxil, Bis(POM)-PMEA) proceeds from adefovir by the action of chloromethyl pivalate (Figure 3) (Starrett et al., 1992)
