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Informed by recent studies from 2024-2025, future research should prioritize the development of disease-specific ferroptosis biomarkers, optimization of combination therapy regimens, creation of next-generation modulators with enhanced cell-type specificity and pharmacokinetic properties, and elucidation of ferroptosis crosstalk with other regulated cell death pathways (152)

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Potential limitations of both studies include the use of a single dose rather than multiple doses of cagrilintide and the use of doses (0.6 mg in the renal impairment study and 0.9 mg in the hepatic impairment study) lower than the 2.4 mg dose being evaluated in clinical development