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It governs a wide array of cellular processes, from antioxidant reactions to redox equilibrium, with a particular emphasis on lipid peroxidation and free iron accumulation processes [32]
Investigators are particularly interested in determining the mechanisms by which effects observed in murine models relate to broader mammalian metabolic regulation, and whether different experimental conditions (young vs aged models, healthy vs metabolically compromised states) show differential responses to NNMT inhibition
Given that the TME is a highly complex milieu, the co-culture system used in this study may not fully replicate the melanoma TME
