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In fact, clinical trials have shown that the administration of carnitine derivatives, such as acetyl-L-carnitine: improved neurophysiological parameters , reduce pain reduced symptoms related to vascular degeneration in diabetic patients
This, in turn, would result in the down-regulation of carbohydrate flux, due to product inhibition of PDC

43 Additional reviews corroborate the superior efficacy of ALC in DPN than in other causes of neuropathy